ESTERO, Fla. - eTradeWire -- Florida Trend, a statewide business magazine, has selected Dr. Arie Dosoretz for its 2026 Florida 500, a prestigious list of the state's most influential business leaders across all industries.

Dosoretz, CEO and managing partner of Southwest Florida Proton, is co-founder and managing partner of Advocate Radiation Oncology and Precision Healthcare Specialists. Combined, the practices employ several hundred physicians, health care professionals and support staff at more than 50 locations in the southern half of Florida.

Florida Trend recognized Dosoretz among 32 leaders in the Health and Life Sciences category. It's the second consecutive year that Florida Trend honored Dosoretz in its annual spotlight. The magazine announced its 2026 honorees on Oct. 30.

Dosoretz opened Advocate Radiation Oncology's first location in 2019. Today, the practice provides cancer treatments from Naples to Bradenton on Florida's west coast and Fort Lauderdale to West Palm Beach on the state's east coast.

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Precision Healthcare Specialists opened in 2023 with a single medical specialty and today has offices and treatment centers from Marco Island to Bradenton. The rapidly growing network's specialties include audiology, breast surgical oncology, colorectal surgery, dermatology, endocrinology, general surgery, head and neck surgery, otolaryngology, orthopedic surgery, pulmonology and urology.

Inspire Oncology, which was founded in 2020, merged with Advocate in 2025, bringing additional Naples-area radiation oncology locations into the fold.

Southwest Florida Proton opened its first phase in December 2024 and second phase in December 2025, becoming the first center along Florida's entire west coast to offer proton therapy, a highly advanced form of radiation therapy that uses charged proton particles to destroy cancer cells with exceptional precision, typically resulting in fewer side effects and less radiation exposure to surrounding healthy tissue. Within six months, the center doubled its hours of operation to meet demand.

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Dosoretz was raised in Fort Myers and attended the University of Pennsylvania, where he earned a bachelor's degree in neurobiology, an MBA and a medical degree. After leaving Philadelphia, Dosoretz completed a residency at Yale University's New Haven Hospital, Department of Therapeutic Radiology, before returning to Southwest Florida to practice as a physician and work in health care management.

Board-certified in radiation oncology through the American Board of Radiology, Dosoretz is a member of the American Society for Radiation Oncology and the American Society of Clinical Oncology. In addition to being a two-time Florida 500 honoree, Dosoretz also has earned a Cancer Care Hero Award from the Lee Health Foundation, Scientific Achievement Award from the Lee County Medical Society and 40 Under 40 Award from Business Observer.