ACE1 Inhibitor Screening Kit (Colorimetric)

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MILPITAS, Calif. - eTradeWire -- Angiotensin-I-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II, by removing a carboxy-terminal dipeptide. ACE is a key part of the renin angiotensin system that regulates blood pressure. ACE inhibitor inhibits ACE1 enzymatic activity and decreases the production of angiotensin II. As a result, blood vessels are dilated thereby increasing the amount of blood pumped by the heart and lowering the blood pressure. ACE inhibitors are used for treating hypertension, heart failure, stroke etc. Recent research is also focused on the discovery of natural products as ACE1 Inhibitors.
BioVision's ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in OD at 345 nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the OD at 345 nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.

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In the validated sample, inhibition of ACE1 activity by Captopril. IC50 was calculated to be 6.61 nM. Assay was performed following the kit K719 protocol.

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Source: BioVision Inc
Filed Under: Biotech

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